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JWH 250 binds with significant affinity and acts as an agonist at G protein-coupled cannabinoid receptors CB1 and CB2. The method of research for JWH 250 consists of using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). This analytical technique has become utilized to evaluate total concentrations in wastewater samples, human serum, and urine samples from subjects that have smoked marijuana.

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